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2022 NFL playoff odds, picks, line, spread: Packers vs. 49ers predictions, bets from expert who’s 50-16


The 2022 NFL playoffs continue with the divisional round this weekend, and the NFC takes center stage on Saturday evening. Aaron Rodgers and the Green Bay Packers welcome Jimmy Garoppolo and the San Francisco 49ers to Lambeau Field with a spot in the NFC Championship Game on the line. Green Bay is the No. 1 seed in the NFL playoff bracket after posting a 13-4 record this season. San Francisco finished 10-7 during the regular season and defeated the Dallas Cowboys on the road in the Wild Card Round.

Kick-off is at 8:15 p.m. ET in Green Bay. Caesars Sportsbook lists the Packers as six-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 47 in the latest Packers vs. 49ers odds. Before you make any 49ers vs. Packers picks and NFL playoff predictions, make sure you check out what SportsLine NFL expert R.J. White has to say.

CBS Sports’ Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It’s no surprise, as White has cashed huge twice in the world’s most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White has gone an astounding 50-16-1 on his last 67 picks involving Green Bay, returning more than $3,100. Anyone who has followed him is way up.

Now, White has set his sights on 49ers vs. Packers, and just locked in his coveted picks and NFL playoff predictions. You can head to SportsLine to see White’s picks. Now, here are several NFL playoff odds and divisional round betting lines for 49ers vs. Packers:

  • Packers vs. 49ers spread: Packers -6 
  • Packers vs. 49ers over-under: 47 points 
  • Packers vs. 49ers money line: Packers -250, 49ers +205 
  • SF: 49ers are 5-1 against the spread in their last six games 
  • GB: Packers are 12-5 against the spread this season

Featured Game | Green Bay Packers vs. San Francisco 49ers

Why the 49ers can cover

The 49ers are allowing only 21.5 points per game and 1.95 points per drive this season, both of which are stellar figures. San Francisco is in the top four of the NFL in total defense, allowing 310 yards per game, and is giving up fewer than 29 yards per possession. The 49ers No. 6 in pass defense and No. 7 in run defense, allowing only 26 passing touchdowns. 

Green Bay is below average on the ground this season, producing only 4.3 yards per rush attempt and 13 rushing touchdowns. The 49ers are also in the top six in first downs allowed and fumbles recovered.

Why the Packers can cover

The Packers are scoring 26.5 points per game this season, finishing in the top ten of the NFL, and Green Bay scored on 44.5 percent of offensive possessions in 2021. The Packers averaged 2.54 points per drive, a top-five mark, and also finished No. 4 in yards per drive (35.9). 

No team committed fewer turnovers (13) than the Packers this season, with Green Bay giving the ball away on only 6.4 percent of offensive possessions. With standout quarterback play, the Packers are in the top eight in first downs (375) and passing yards (4,315), with a top-five mark with 39 passing touchdowns. Beyond the overall turnover avoidance, the Packers led the league with only seven interceptions, and completed 67.8 percent of passes while averaging 7.6 yards per attempt.

How to make 49ers vs. Packers picks

White has analyzed this matchup and while we can tell you he’s leaning under on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side of the Packers vs. 49ers spread to back, at SportsLine.

So who wins 49ers vs. Packers in the NFL playoffs 2022? And what critical X-factor makes one side of the Packers vs. 49ers spread a must-back? Visit SportsLine now to see White’s 49ers vs. Packers picks, all from the NFL expert who’s 50-16 on picks involving Green Bay, and find out.





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MD Abdullah
Abdullah is a former educator, lifelong money nerd, and a Plutus Award-winning freelance writer who specializes in the scientific research behind irrational money behaviors. Her background in education allows her to make complex financial topics relatable and easily understood by the layperson. She is the author of four books, including End Financial Stress Now and The Five Years Before You Retire.
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