HomeHealth & FitnessIntroduction to Leukemia Inhibitory Factor (LIF) & Cystatin C Levels

Introduction to Leukemia Inhibitory Factor (LIF) & Cystatin C Levels

Cystatin C is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. When you search for ‘what is cystatin c test’, you will come across other aliases for Cystatin C are cystatin 3, formerly known as post-gamma-globulin, neuroendocrine-basic polypeptide, and gamma trace. Cystatin C is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. CST3 gene encodes cystatin C, which belongs to the gene family of type 2 cystatin. The CST3 gene is present in the cystatin locus on chromosome 9.

The cystatin C levels test is a biomarker for kidney disease. It measures the levels of cystatin C present in blood and sometimes cerebrospinal fluid. A high level indicates the presence of kidney impairment, whereas a low level may signify a healthy kidney or impaired thyroid gland. You can measure cystatin C levels and the glomerular filtration rate (GFR) to detect kidney disorders. Cystatin C is a protein that helps protect your body from enzymes that break down your muscles, cells and organs. A cystatin c test measures the amount of this protein in your blood. When kidney function drops below 35 mL a minute, cystatin C levels begin to rise in the bloodstream and this is useful to measure kidney function.

Leukemia inhibitory factor (LIF) is a cytokine encoded by the LIF gene. LIF is an IL-6 class protein that inhibits cell differentiation, affecting cell growth. A decrease in LIF levels signals the cells to differentiate. In developing embryos, trophectoderm expresses LIF. LIF binds to LIF-receptor (LIFR),present throughout the embryonic inner cell mass. During the blastocyst stage, the inner cell mass produces embryonic stem cells, and if we remove these cells from the inner cell mass, the embryo loses its LIF source. LIF is produced as a 202 amino acid precursor protein. Upon removing 22 amino acids post-translationally, it processes the precursor protein into a 20 kilodalton active form.

Leukemia inhibitory factor review cytokine encoded by the LIF gene. LIF is an IL-6 class protein that inhibits cell differentiation, affecting cell growth. A decrease in LIF levels signals the cells to differentiate. In developing embryos, trophectoderm expresses LIF. LIF binds to LIF-receptor (LIFR), present throughout the embryonic inner cell mass. During the blastocyst stage, the inner cell mass produces embryonic stem cells, and if we remove these cells from the inner cell mass, the embryo loses its LIF source. The leukemia inhibitory factor (LIF) is a cytokine encoded by the LIF gene. A member of the IL-6 family of cytokines, it inhibits cell differentiation and influences cell growth. In developing embryos, following implantation in the uterus, cells from an inner cell mass migrate into an outer layer called the trophectoderm; these trophoblasts produce LIF, which promotes proliferation of cells in the inner cell mass to produce embryonic stem cells. As embryo development continues, LIF becomes less abundant in the morula and obliterated altogether in late blastocyst stage.

RELATED ARTICLES

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisment -
Google search engine

Most Popular

Recent Comments

Help on Hello world!